1831- April 2, Pennsylvania State Assembly passes act providing for the incorporation of the Cumberland Valley Railroad Company. Charter stipulated that construction must begin within three years and be completed within seven years.

1835- Nicholas Biddle led efforts to revive the charter after efforts to raise money and begin construction fell short of the three year deadline. By June 2, enough stock was raised for Governor Ritner to issue letters of patent to the CVRR 

1837- August 12, first section of CVRR complete from Carlisle to the Susquehanna River; November 16, Carlisle to Chambersburg portions open with a stop in Shippensburg.

1839- CVRR introduces some of the first sleeping cars in the nation. Union Hotel built in Shippensburg, served as the passenger station until 1876.

1844- December 4, Susquehanna River Bridge burns down, results in the company’s single largest loss in its history.

1846- Pennsylvania Railroad begins construction on a line from Harrisburg to Pittsburgh.

1848- First rebuilding of the railroad is authorized and construction begins by replacing the tracks with sold iron rails.

1849- Passenger service becomes 40% of the total revenue of CVRR.

1856- January 1, railroad from Harrisburg to Pittsburgh opens.

1859- Pennsylvania Railroad buys a controlling interest in the CVRR.

1860–1890 PRR expands through the Eastern US by acquiring controlling interests in smaller lines.

1862- Confederate forces destroy CVRR buildings and property during the Antietam Campaign and burn the depot at Chambersburg.

1871- Cumberland Valley Normal School opens.

1870s–1880s- Feeder lines to areas such as Mont Alto and Mechanicsburg and the expansion of the CVRR.

1919- The Pennsylvania Railroad merges with the CVRR and it becomes the Pennsylvania Railroad.

1946- April 13, PRR celebrates its one hundred year anniversary.

1968- February 1. PRR merges with the New York Central to form the Penn Central Transportation Company.

1970- Penn Central declares bankruptcy

1971- Amtrak takes over the passenger service of Penn Central.

1974- January 2, President Richard Nixon signs Regional Rail Reorganization (3R) Act of 1973 into law creating Conrail.

1978- Conrail spends all of the $2.1 billion authorized for its rehabilitation in addition to $490 million in private sector financing.

1980- October 14, President Jimmy Carter signs the Staggers Rail Act giving railroads the freedom to adjust prices in response to market conditions and tailor rates to specific conditions of various industries and types of freight.

1981- May 1, last train runs through Shippensburg.

1985- August 7, last tracks through Shippensburg on Earl Street are removed.